12 Angry Men Movie Analysis Essay

After the jurors go to the meeting room to discuss and arrive at consensus whether the young boy is guilty or not, we get to see different personalities combined to form a group to resolve the issue. Initially 11 out of 12 jurors voted in favour of boy being guilty. Therefore, first prominent thing I noticed was that there was lack of conviction about the criticality of the issue. People had already formed their judgement before they stepped into the meeting room. They believed the testimonies of several eyewitnesses and the arguments of the prosecutor leading to the conclusion that the boy was guilty. In the beginning, 11 out of 12 jurors were not sensitive about the seriousness of the decision they were going to make and the impact it was going to have on the young boy’s life. They were not ready to waste any time over discussing that issue because they had already perceived the young boy guilty based on his background and crimes he committed before as well as the jurorsâ₠¬â„¢ previous experiences in life. See more:  Manifest Destiny essay When the protagonist in the movie showed opposition to agree the boy’s guilt, then the rest of the people became frustrated since they had to come to consensus to give a judgement. This showed the conviction and thoughtfulness of the protagonist to the criticality of their objective as jurors. It was also evident that being a minority does not mean you have to go majority’s way under the influence or pressure of majority against your wish. After listening to the protagonist, juror started changing their original guilty decision one by one. This showed their willingness to change their stance having been convinced by the protagonist’s logic. Protagonist stuck to the practicality of the situation and logic in order to bring the possible flaws in the testimonies of the eye witnesses by reproducing the situations and verifying the possibility of authenticity of the testimony. In doing so, he influenced the members of the group that there are lacunae in the testimonies, and the benefit of doubt needs to be given to the boy when it is a matter of his life and death. The various people in the group started applying their mind and making sense of the possible flaws in the testimonies. Many started to pitch in their ideas and the protagonist was listening to them all and using them to strengthen his hypothesis of uncertainty about boy being guilty. Now they started utilizing the resources in the group to make the most informed decision. The group dynamics was at work the best. They were supplementing each other’s logic by their own logic in order to make a conclusion of the veracity of the evidence and its testimony. There were a couple of aggressive people in the group. When one of them lashed out at the old man in the group, another person intervened and warned him not to repeat insulting behaviour. Thus, along the way the group stated forming norms about the behaviour in the group. Also, when one man changed his judgement just for the sake of it in order to come to consensus sooner than later, then another person made it a point to him by saying that he needed to present his logic for changing his decision and he did not want to accept his ‘yes’ or ‘no’ just for the sake of it. Some people engaged themselves in social loafing without regard to the seriousness of the objective; they were reminded of the objective by others. Last person — son left so he was seeing his son in the young boy. 12 Angry Men Movie Analysis Essay Introduction: This movie analysis will focus on the movie 12 Angry Men. There will be comparisons between the movie and the different negotiation tactics used in the movie and even in class. There were lessons learned from this movie and it gave new ways of thinking. This movie does a great job of using negotiation to win over a case when you are the odd man out. Summary: This movie focuses on a jury deliberating a first-degree murder charge on an eighteen year old boy. The boy is accused of stabbing his father to death. If found guilty of the charges, the eighteen year old boy will face the death sentence. There are many reasons as to why the boy looks guilty. He has a weak alibi, he claims to have lost the knife he bought, which was the same knife found at the murder scene, and there are witness’s saying they either saw the killing or saw the boy leaving the apartment. Out of the twelve jurors, eleven of them think the boy is guilty, except one. This is juror number eight. He claims he just does not know if the boy is guilty or not guilty, and wants to talk. The entire juror’s quickly begin naming all the reasons why the boy is guilty. For each reason, juror number eight questions each reasoning the other jurors bring up. He states a lot in the movie â€Å"is it possible?† This question starts to put doubt in the other juror’s minds about the boys’ guilt. Also with the ongoing deliberation, the jurors are starting to learn more about themselves and their personalities and this is causing them to vote â€Å"not guiltyâ€Å". Some realize they are prejudice or are holding grudges, or they are simply voting guilty because of their backgrounds. With each reason and deliberation, juror number eight continues to attempt to convince the other jurors that voting â€Å"not guilty† may not actually be correct. Juror eight is hesitant about sending a boy to die without talking about it first. He does think that from the trial the boy is guilty, but he’s just not too sure about it. He remains calm throughout the whole deliberation. The only time he shows signs of anger is when two other jury members start playing tic-tac-toe. This bothers him because everyone should be paying attention to what is going on and not playing games. He questions every incident with â€Å"Is it possible?† The best negotiators spend time asking questions, staying curious, and uncovering the other side’s views of the situation, facts, interests, and priorities. Throughout the deliberation, he uncovers information never presented at the trial, and helps the other jurors to think that it just may not be possible the boy could be guilty. Characters & Personalities: Each character in the movie has a different personality about them which influences their decision on the verdict and they each express their own opinions based on their characteristics. Each juror plays a part in the movie where their personalities reflect back on a certain argument in the case. Juror one (Martin Balsam) is also known as the foreman of the group. He is put in charge to run the deliberation between all of the jurors. He likes that he has authority to run the group, but isn’t very assertive in doing so. Juror two (John Fiedler) is quiet and goes along with what everyone else says. He changes his vote early, though, to not guilty. He mentions about the height difference between the father and the boy, and how the boy would go about stabbing him. Juror three (Lee J. Cobb) is the angry member of the group. He is convinced the boy is guilty no matter what anyone says. He sees no point in discussing the boy’s innocence. There comes a time in the movie where he discusses that when his son was fifteen, he got in a fight with him and his son hit him. He hasn’t seen his son ever since. Juror three is angry with his son for his actions and for leaving, that he is taking out this anger on the boy in trial. Juror four (E.G. Marshall) is very convinced that the boy is guilty. He shows no sign of emotion and is able to recall much of what happened throughout the trial. He gets nervous though, as he cannot recall a certain movie he saw the other night, just as the boy could not do the same. Juror five (Jack Klugman) is a shy man. He lived in a slum all his life and can almost relate to the boy on trial, for he lives in a slum as well. He is an expert at using a switch knife, which comes in handy during the deliberation. Juror six (Edward Binns) is quite during the deliberation. He questions the boys’ motive for wanting to kill his father. Juror seven (Jack Warden) wants the deliberation to be over as quick as possible because he has tickets to a baseball game later that evening. He votes not guilty and does not wish to discuss why or why not. Juror eight (Henry Fonda) votes not guilty from the start of their meeting. He doesn’t know for sure if the boy is not guilty; he just wants to talk about it. He manages to cast reasonable doubt with the jurors on the boy’s innocence based on many aspects of the trial. He remains clam and patient throughout the deliberation. Juror nine (Joseph Sweeney) is an old man. He is the second person to vote not guilty, for he wants to hear more about the case. He is very observant, as he notices something about one of the witness’s during the trial. Juror ten (Ed Begley) is also an angry man. He is racist, and also very prejudice against people who come from a slum, which is why he believes the boy is guilty. Juror eleven (George Voskovec) takes the trial seriously. He stands up for what he believes in. He questions the boy’s actions a lot; such as if he really would have returned the his house three hours after the murder happened. Juror 12 (Robert Webber) is a smart man. He works for an advertising agency and has a hard time explaining his choice for changing his vote to not guilty. During the deliberation, certain parts of the character’s personalities play a part for different concepts. One example is with Juror five. During the trial, the boy was convicted of murdering is father using a switch knife as the weapon and stabbing his father down in the chest. Juror two makes a point on the height difference between the boy and his father, and how the boy would proceed to kill his father, meaning how he would have stabbed him. Juror five explains that he used to play with switch knives when he was around the boy’s age, and knows how to use one. During the trial, it was stated that the boy was an expert at using a switch knife. Juror five goes to demonstrate exactly how the boy would have pulled out the knife and stabbed his father: from underneath. He said it would take too much time to switch hands and stab down in his chest. Without Juror five having the knowledge and his personal characteristic of using a switch knife, the jury would have never learned how an experienced knife handler would have used the weapon. Tactics: In this section we will talk about a few of the tactics that we got the actors/characters using during the film. A few of this tactics were talked about during our class and case studies but some of the tactics were commonly used in everyday negotiations by everyone. We talked about power and how you could use power to get your way; you could use facts against the other party because facts are something you cannot ignore and emotions. Emotions are a hard tactic to master because you need to set aside your emotions so you can make a fair and honest judgment or answer. Power: Juror eight shows power over the other jurors. He has information the other jurors do not know about, and he is able to negotiate with them more. Information power is derived from the negotiator’s ability to assemble and organize facts and data to support his or her position, arguments, or desired outcomes. The other jurors only listened to what was presented in the trial. But Juror eight actually thought about the facts presented, and went out to look for more information. One way he did this was with the knife. The boy had bought the same knife used to kill his father the same night the murder happened. The boy claimed he had lost the knife, as it had fell through his pocket on his way to the movies. The owner of the shop where he had bought the knife claimed it was very unique, and he had never seen any other kind like it in his store. Juror eight asks to see the knife found at the crime scene. Everyone else is convinced this is the same knife the boy had bought, until Juror eight surprises them and pulls out the exact same knife. He says that he went out walking the previous night in the boy’s neighborhood and came across a shop just two blocks away from the boy’s house. He saw the same knife and bought it at a cheap cost. He proved to the other jurors that it is possible the boy could have dropped his knife, because that knife isn’t as unique as the thought. Another part where Juror eight has power is when they are debating about whether or not the old man heard the boy scream â€Å"I’m going to kill you!† According to the testimony, the boy had yelled those words right as the L-Train was passing by the window. Is it possible the old man heard the boy scream that? Juror eight stated that he had lived in an apartment next to the L tracks before and the sound of a train passing by is unbearable. Another juror said he had just finished painting one of the apartments and agreed that the sound is very loud. Juror eight had power over the others for he himself knew that the sound was very loud and it may not be possible the old man heard the boy say these things. Presentation of Facts: The way the facts were presented during the movie were all facts the jurors figured out themselves while deliberating, and not during the trial. There were many unanswered questions during the trial which caused Juror eight to question whether the boy was guilty or not. The defense attorney left out a lot of important information that was uncovered during the jury’s deliberation. One of these facts dealt with the old man who claimed he saw the boy running down the stairs from his apartment. The more the jury talked about the old man and what he said, the more Juror eight questioned if he had really seen the boy or not. One of the jurors pointed out that the man was dragging his left foot behind him, but trying to cover it up because he was ashamed. During the trial, the old man stated he heard a body hit the floor, and someone starting to run. He then said it took him no more than 15 seconds after he heard the body hit the floor to run out of his apartment and to the stairs to witness the boy running down them. Juror 8 thought then if it really could have taken him 15 seconds if he was dragging his left leg. This is when the jurors played out the scene to figure it out themselves. They were able to get a diagram of the apartment and measure out the dimensions of the room they were in. Juror eight walked the length of the room and back, while Juror two timed him. As he approached the end, Juror 2 said it took 41 seconds to walk the length they had measured out. By playing out the scene of the old man, this proved the fact it could not have taken the man 15 seconds, and he could not have seen the boy running down the stairs. Another important fact happened during the very end of the deliberation. At this point, everyone but two people believed the boy was innocent. Juror four says his reasoning for believing the boy is guilty is because of the woman across the street who claims she saw the murder herself. As he is talking, he takes his glasses off and begins rubbing the outside part of his nose where his glasses lay. Juror nine notices this, and asks him why he rubs his nose like that. Juror four says it is from his glasses, that they bother his nose, so he rubs him. Juror nine notices the markings on his nose from his glasses, and recalls the woman had the exact same markings on her face. He then asks Juror four if there is any other possible way to get those same markings on his nose, and he replies no. Juror eight then starts to say that the woman was lying, for she did not see the boy kill his father, for she was trying to fall asleep, and she wouldn’t be wearing her glasses to bed. These two examples show how hidden facts slowly come out. This is information left out from the trial that everyone missed, until now. After proving these statements, the jurors started to have doubt in their minds about the boy. It’s important to look at every aspect in as much detail as possible or you could miss out on something. Sure, the old man can say it took him 15 seconds, but as it turns out, it took him longer than that. And sure, the woman can say she saw the boy kill her father, but really all she saw was a blur, for she did not have her glasses on. You can’t always go by what you hear. You have to dig deeper to discover any hidden information that could help against your situation. This is what Juror eight did and it helped support his case. Also from these two examples, it goes to show that you can’t always believe what you hear. The witness’s both were under oath as they spoke in trial, but they could just be doing that for attention. Juror nine points this out for the old man, as he can relate. He is old and unnoticed. He just wants attention, so he could have made himself believe he saw the old man when he really didn’t. As for the woman and the glasses, she didn’t wear her glasses to the trial because she wanted to upgrade her appearance. So she said she saw the boy, seeing as if she didn’t wear glasses at all, but really she did for she had the markings on her nose. Emotions: Negotiations often evoke a variety of emotions, especially fear and anger. Emotions can cause intense and even irrational behavior, and can cause conflicts to escalate and negotiations to break down. Juror three from the start showed angry signs of emotion throughout the whole deliberation. He stated how he hadn’t seen his son in two years, and all his anger from his son is taken out on the boy on trial. Juror three wants everyone to agree with him. No matter what information is presented, he sticks with his vote of guilty. He gets mad whenever evidence is brought up or someone proves something wrong. His emotions reach a peak whenever Juror eight calls him a sadist. At this point, Juror three lunges toward Juror eight saying â€Å"I’ll kill him!† Then Juror eight replies, â€Å"You don’t really mean you’ll kill me, do you?† This proves his point about how sometimes people say things they really don’t mean. His emotions got the best of him, and he realized that he really wouldn’t kill the juror. Having your emotions from your personal life come into play during a negotiation is not always a good thing. Juror three should not have taken his anger out on the boy or even on Juror eight because of his son. He was angry at his son for leaving, but he should have put that aside for the deliberation. Having your emotions lay out like that on the table can cause you not to think about the important facts that need to be focused on. Juror eight shows emotion in a positive way. He stays very calm throughout the whole deliberation. By showing no sign of angry emotion, this allows him to keep his composure and control of what he is trying to get across. If negotiators feel positively attracted, they are more likely to feel confident and, as a result, to persist in trying to get their concerns and issues addressed in the negotiation and to achieve better outcomes Bias: I’d like to spend some time discussing an issue that I feel is very important to recognize when it comes to negotiations. This is the issue of bias. We had several discussions in class about bias. The thing that most fascinates me about the concept of bias, is that everyone tends to have a different opinion about it. It can be a very grey area, and many people have varying feelings on its presence and its effect on people’s behavior. Personally, I feel that it’s impossible to completely eliminate all bias from a situation. Even when looking at something objectively, bias still exists. It comes from personal characteristics, experiences, and opinions. This movie does a great job of showing how bias can have an effect on negotiations. I’d like to cite an example from the film regarding juror number ten. This juror is an old man who is very set in his ways. He is among the eleven jurors who found the boy guilty of murder. However, his reason for voting guilty comes from a very different place than the others. The evidence seems to favor a guilty vote, but the film shows us that this gentleman’s vote was sealed the minute he learned the boy was from a slum. During the deliberations, this juror seconds an argument made by a fellow juror. He says, â€Å"Brother, you can say that again. The kids who crawl out of these places are real trash.† Regardless of this evidence, this shows a bias against the boy from the start. This man is allowing his prejudice against â€Å"slum dwellers† to influence his decision about the verdict. The juror across the table then takes offense to this comment. â€Å"I’ve lived in a slum all my life,† says the juror. This should quell the old man’s argument, but it doesn’t. He still feels strongly about his position, even though a man from a similar background clearly hasn’t followed a path that â€Å"trash† might follow. This demonstrates the power of bias. The greatest example of overcoming bias in this film occurs in the very last minutes. By this point, the jury has reached a vote of 11 to 1 for â€Å"not guilty.† The lone juror who still maintains the boy’s guilt is juror number three. This is the man who hasn’t seen his own son in over two years. Earlier in the deliberations, he explained how he and his son got into a fight when the boy was still a teenager. His son hit him, and things were never the same between them. As the talks between the jurors continues, it becomes more and more evident that this man has a bias against the boy on trial because of what transpired with his own boy. He wants to see this boy killed because he resents his own son for what occurred between them. The initial juror who voted â€Å"not guilty† went as far as calling him a â€Å"sadist† and a â€Å"public avenger.† In the final scene, that juror asks the man to defend his arguments one last time. There is a re asonable doubt in the minds of eleven jurors, and he wants to know why there isn’t one in his. Juror number three begins explaining, yelling the entire time. You can see him getting more and more upset as he continues to pour over evidence that the other men have already proven shaky. Finally, he rips up the picture of him and his son that has slid out of his wallet on the table. He then bursts into tears and cries, â€Å"Not guilty, not guilty.† It was clearly painful for him to confront what happened with his son head on like that. This was creating his bias the entire time. When the evidence appeared to support the boy’s guilt, his bias was less prevalent. But when the evidence that started out convincing ended up being questionable, his bias began to show. He still wanted the boy to be found guilty because of it. This really makes you wonder how often this occurs in the real world. How many innocent men and women have been sent to jail because of biased members of a perceived â€Å"impartial† jury? It’s an imperfect system, dealing with a very i nexact science. Recognizing this is very important. From this course, and from analyzing this film, I have strengthened my belief that bias can’t be eliminated. All a negotiator can do is recognize that bias is constant, and do their best to minimize its effect on their decision making process. If a negotiator recognizes this, they can do more negotiating based on facts and figures rather than personal biases and opinions. Power and Persuasion: An interesting aspect of this movie, as it continues to relate to this course, is the use of power and persuasion. What I find most interesting about power, is the myriad of ways through which it may be obtained. In class, we discussed several ways that power is obtained, and also how it can be used. In this movie, there are many circumstances where the jurors attempt to use power to persuade one another. Perhaps the most prevalent example at an attempt to use power to persuade the others is shown by juror number three. This juror often exudes power when talking down the case with the man who hasn’t turned in a â€Å"guilty† verdict. He begins by explaining all of the evidence again. He discusses the old man who claims he heard the boy, the old lady who says she saw the boy, and the knife discovered by the police who arrived at the murder scene. He is very confident in this evidence, and feels as though he has the power because of it. After taking this course, I find that this is the best way to gain power in a negotiation. The more information you have to support your argument, the more power you have. In turn, this often results in achieving your goals in the negotiation. However, as the process continues, the juror voting â€Å"not guilty† starts to sway the room. The oldest man on the jury is the first to change his vote. The juror from the slums changes his vote not long after that. As this is happening, it appears that juror number three feels as though he is losing power in this negotiation. To counter this, he begins raising his voice when talks. Before long, he is all but yelling at the other jurors who have changed their votes. He attempts to retain his power through intimidation once he sees that the evidence, which he thought was solid, is shown to be shaky and imprecise. Another example of how power is used to persuade others in this film is demonstrated by the stock broker, otherwise known as juror number four. It appears that this juror feels an immediate sense of power in this scenario because he is one of the most, if not the most, accomplished gentleman of the group. He feels that he is probably the most intelligent man on this jury, and demonstrates that when talks. He recalls much of the information from the trial very accurately, and with no notes. He also explains very clearly why he feels the way he feels. Power through intellectual superiority can be very persuasive, and influential. The man he is attempting to persuade does a very good job of keeping his composure. He doesn’t challenge the broker’s power. In fact, he affirms it. He appears to respect that the juror is making valid points and supporting his argument. He goes a different route. He simply takes an issue and asks, â€Å"Is it possible?† While the other jurors refute this claim, the broker remains quiet. As the man slowly begins to disprove some of the testimony from the case, you can see the broker questioning his verdict more intently. Finally, he changes his vote to not guilty. This is where everything turns. The other jurors picked up on the quiet power exuded by the broker, and respected it all along. Once he turned in a â€Å"not guilty† vote, it was only a matter of time before the others joined him. This is convincing tell that this man had a great deal of power in this negotiation. In a less successful attempt to gain power, the angry old man attempts to convince the man of the boy’s guilt through a â€Å"power in numbers† technique. He feels very comfortable with his verdict of â€Å"guilty† because the others feel the same way. During the initial discussions in the deliberation room, he continuously says, â€Å"You know what I mean?† This is an attempt to keep others on his side while he tries to persuade the rogue juror to vote â€Å"guilty.† He feels he has power in this negotiation because he has the majority on his side. This is a common tactic in negotiations. As the film progresses and more and more jurors change their verdict, you can easily see the power leaving the angry old man. He is forced to confront his prejudice and accept that he was wrong. When he is no longer in the majority, his sense of power quickly fades. He becomes defensive and weak as more and more people leave his side. This is most prevalent in the scene where he attempts to defend his â€Å"guilty† vote one last time. He stands up, and continues yelling and shouting his narrow minded opinions, much as he’d done the entire time. His arguments, now more than ever, are being entirely disregarded, and for good reason. Each point he is making is based solely on prejudice. He thinks he is powerful, but nothing he is saying is based on fact, or really has anything to do with the case. One by one, the other jurors begin getting up from the table and ignoring him. Even the juror who was consistently making wise cracks during the deliberations is looking away from him. Soon, no one in the room is backing him. He then retires to the corner, alone. He not only lost the majority, he lost the support of the other men who were still turning in a â€Å"guilty† vote. This is a great example of power shifting, which we discussed in class. You asked us if it’s possible for power to shift during a negotiation, and this is a good demonstration of how it can. Works Cited: Ang, S., Van Dyne, L., & Koh, C.K.S. (2006). Personality correlates of the four factor model of cultural intelligence. Group and Organization Management, 31, 100-123. Diamond, S. (2010). Getting More: How to Negotiate to Achieve Your Goals in the Real World. New York City, NY: Crown Publishing Group. Earley, P.C., & Ang, S. (2003). Cultural intelligence: Individual interactions across cultures. Palo Alto: Stanford University Press. Gates, S. (2011). The Negotiation Book: Your Definitive Guide To Successful Negotiating (1st ed.). United Kingdom, UK: John Wiley and Sons LTD. Shell , R. G. (2006). Bargaining for Advantage: Negotiation Strategies for Reasonable People 2nd Edition (2nd ed.). New York City, NY: The Penguin Group. Thompson, L. L. (2008). The Truth About Negotiations . Upper Saddle River, NJ: FT Press.

Chinese philosophy Essay

. Introduction A. Thesis There are so many different philosophies and religions, and they greatly influence people’s life. In this paper, I am going to introduce and define the representatives of the Western philosophy such as Plato’s metaphysical Dualism and Chinese philosophy like Daoism. And I am going to compare these philosophies and explain the difference between them. ?. Dualism A. Explain Plato’s metaphysical Dualism Plato’s Dualism divided the reality into two different realms of existence (World of the Senses and World of the Forms). One world (the physical world) is constantly changing, and another world (the world of the Forms) is unchanging. Plato further divided these two different realms of existence. The world of Forms can be divided into the higher world (realm of the form) and the lower world (the Empirical world). The world of senses can be divided into physical objects (ordinary objects we perceive) and images (shadows, reflections and pictures). B. Summary of Allegory of Cave Plato explained his metaphysical dualism by using the Allegory of a cave. According to Marc Cohen: In the allegory, Plato likens people untutored in the Theory of Forms to prisoners chained in a cave, unable to turn their heads. All they can see is the wall of the cave. Behind them burns a fire. Between the fire and the prisoners there is a parapet, along which puppeteers can walk. The puppeteers, who are behind the prisoners, hold up puppets that cast shadows on the wall of the cave. The prisoners are unable to see these puppets, the real objects that pass behind them. What the prisoners see and hear are shadows and echoes cast by objects that they do not see. However, one day one of them is released from what keeps them the guy sitting, and they look back. At that time, the guy realizes that there are objects and the fire behind people and someone moves the objects. The shadow people have seen is a fake. People who are still sitting have never seen the objects behind them, so they believe that the shadow is real. The guy is free to move, so he starts to run to the exit of the cave. After getting out of the cave, the guy feels dizzy because the world out of the cave is too shiny. After a while, his eyes got used to the brightness and the beautiful world like the mountain, the sky, the river, or the sun is in the eyes of the guy. And then he realizes that the world out of the cave is real. He goes back to the cave and tells people who are still sitting in the cave what he saw out of the cave. However, they do not believe that what the guy told is the truth. C. Interpretation of the Allegory By using this Allegory, we can think about today’s world. There are too much in formation in the world, and the world seems to be narrower than before. Especially the appearance of mass media like newspaper, television, magazine, Internet, or SNS changed how we deal with information. Too much information is created and flows every day, and we can get the information you need any time by the device like a smart phone, a PC or a tablet. However, is the information you can get really the reality? The information created by mass media might be like the shadow in a cave. Before I was born, there was already too much information. I learned much information like Japanese history in a school, and I also know the new information of the incidence that occurs every day at the same time through mass media. So I learned most of things that occurred around the world through the information created by mass media, and the information is like a shadow in Allegory of a Cave. Suppose that an internal warfare is happening in one country. We know about that through mass media. We might see suffers in a TV or in a photo. We feel like understand everything about the war through the picture on TV or words of the News, but that is not a whole thing but just part of that. We need to seek the reality by my own eyes today’s world. ?. Plato’s Legacy According to Philip, â€Å"Plato thought that the soul could and would exist apart from the body and would exist after the death of the body. He offered a â€Å"proof† for this position and was the first to do so in writing that we have any evidence of doing so. He offered several different proofs or arguments none of which are convincing today†. His argument was that humans were composed of bodies and souls, but soul was more important and immortal. His arguments used premises that are questionable today. For example, Plato thought he could conclude that the soul could exist separating from the body because it worked independently from the body when it engaged in pure thought. But today, it is proved that how we think depends on the physical brain works. So this is no longer accepted as true. Plato thought that they are remembering the knowledge implanted in their souls when the souls were in the realm of pure thought and eternal forms before entering into the body after which they forgot as they became confused by physical emotions and feelings and limited experiences through the senses. And that is the only way to explain how people come to know. This is no longer accepted as the best explanation of how people come to have knowledge. However, Plato is credited with being the first human to attempt to set out any sort of a proof that humans had souls and that they survived the death of the body and that they were immortal. A. Descartes-Substance Dualism According to Philip, â€Å"Descartes also believed that the soul existed prior to and separate from the body, and it was immortal. In his view, all of reality consisted of two very different substances: matter or the physical and spirit or the non-physical. † The physical was what would be extended in time and space and the non-physical would not be characterized. He thought that his famous claim that â€Å"I think therefore I am† established not just that he existed but that he existed without a body as a â€Å"thinking thing†. A â€Å"thinking thing† is a thing that thinks and by that would be included: imagining, conceiving, hoping, dreaming, desiring, fearing, conjecturing, reasoning, remembering and more. For him a â€Å"thinking thing† needed no physical parts to do what it does. Modern science has established that there is no evidence of humans that are without a physical body and its brain. There is no evidence that thought is possible without a brain. There is much evidence that what has been associated with Descartes’ â€Å"thinking thing† is now explained solely in term of the brain and how the brain is physically structured and the functioning of the brain. B. Aquinas According to the text, â€Å"Saint Thomas Aquinas is the philosopher who explained five ways to demonstrate the existence of the God within the framework of a posteriori (the knowledge comes from, or after the experience) and developed cosmological and teleological arguments. † I am going to explain one of the demonstrations. The way is from the nature of efficient cause. In the world of sensible things, there is an order of efficient causes. It never happens that the thing is the efficient cause of itself. If you look at one phenomenon, you can see many efficient causes behind it. But you cannot go back to infinity. There must be the first efficient cause. Aquinas claims that that is the God. The Aquinas’ claim is similar to Plato’s claim. He thought the God is the first efficient cause and independent one. That is close to the concept â€Å"the realm of the form† Plato claimed. And the things in the world of sensible things are the secondary things of the God. It is close to â€Å"the Empirical world† Plato claimed. ?. Chinese Natural Cosmology A. Ames `Image of Reason in Chinese Culture† Ames claims the difference between the dominant conceptions of reality in the West and in the Chinese tradition in his â€Å"image of Reason in Chinese Culture†. According to the text, Ames claims that â€Å"to explore the Chinese philosophy, he thought you needed to recognize at least that you are dealing with a fundamentally different world if you are familiar with Western culture. To bring into relief certain features of the dominant Indo-European view and Chinese alternative to it, he constructs a â€Å"logical sense of order with an â€Å"aesthetic† order. † What we call â€Å"logical† sense of order has developed Western philosophical and religious orthodoxy, and it is based on the presumption that there is something permanent, perfect, objective, and universal that disciplines the world of charge and guarantees natural and moral order-some originative and determinative arche, an eternal realm of Platonic edios or â€Å"ideas†, the One True God of the Judeo-Christian universe, a transcendental strongbox of invariable principles or laws, an annalistic method for discerning clear and distinct ideas. In a single-order world, the One God is the initial beginning of the universe. The God is primal and unchanging principle that causes and explains that origin and issues everything from itself, and that is familiar and presupposition in Western tradition. Although the world is explained by â€Å"logical† order in Western tradition, however, there is no â€Å"logical† order in Chinese philosophy. The order of Chinese tradition is immanent in and inseparable from a spontaneously changing world. The universe possesses within itself its organizational principles and its own creative energy. In the view of Chinese tradition, the world creates itself. That is scandalous from the view point of Western scholar reason. The yin and the yan come together and guide the infinite combination of these two opposite source of energy. These two sources of energy make a spontaneous intelligence possible. Yin and yan as the characterization of a particular relationship invariably entail a perception from some particular perspective that enables us to unravel patterns of relatedness and interpret our circumstances. They provide a vocabulary for sorting out the relationship among things as they come together and constitute themselves in unique compositions. Ames also mentions the Chinese word â€Å"li†. In both classical Chinese corpus and modern language, the closest term that approximates â€Å"reason† or â€Å"principle†. He claims that identifying the meaning of the word â€Å"li† correctly is essential to understand Chinese philosophy. According to the text, â€Å"Philosophically, the most familiar uses of li lie somewhere in the cluster â€Å"reasoning† or â€Å"rationale† (A. S. Cua), â€Å"principle† (W.T. Chan), â€Å"organism† (J. Needham), and â€Å"coherence† (W. Peterson). † Among these several alternative translations used for â€Å"li†, although philosophically as protean as â€Å"principle† for Western tradition, unwarrantedly restrict li to a notion of human consciousness and tend to introduce distinction such as animate and inanimate, agency and act, intelligible and sensible. Li is much different from being some independent and immutable originative principle that disciplines a recalcitrant world. It is the fabric of order immanent in the dynamic process of experience. That is why â€Å"psychology† is translated in to Chinese as â€Å"the li of the heart-and-mind,† but then â€Å"physics† is â€Å"the study of the li of things and events. † What separates li rather clearly from Western common understanding of â€Å"principle† is that li is both a unity and a multiplicity. Li is the coherence of any â€Å"member of a set, all members of a set, or the set as a whole. † Both the uniqueness of each particular and the continuities that obtain among them are reflected by this description. Li then is the defining character or ethos of a given community, or any other such composition. Ames also claims another point at which li departs from â€Å"principle. † In Western tradition, the discovery of originative and determinative principle gives us a schema for classifying things and subsuming one thing under another. That is why people seek â€Å"principle† in Western tradition. However, the investigation of li, by contrast, is to seek out patterns that relate things, and to discover resonances between things that make correlations and categorization possible. B. Hans-Gorg Moeller In Daodejing, the meaning of â€Å"the root† is described by using metaphor. From the view of the Daoist, our world is a â€Å"self-generating† process. In Daoism there is no initial beginning for â€Å"logical† order. In Daoism, order is immanent in and inseparable from a spontaneously changing world, and then â€Å"the world creates itself. † In this point of view, the role of â€Å"the root† is very important. â€Å"The root† is an origin of phenomenon, and many things are derived from â€Å"the root. † Unlike many Western philosophical perspectives, this â€Å"root† has a somewhat unique, interesting, and different meaning in it. The Western philosophy’s principle or arche is the first cause of the event. And nothing would exist if there were not any of the Western philosophy’s principle or arche. However, the concept of â€Å"the root† is different of that. From the Daoist perspective, â€Å"the root† is a part of the plant. â€Å"The root† does not exist before the plant although plant cannot exist if there is no â€Å"the root. † That is, â€Å"the root† itself is not a creator of the plant. It is the origin of the growth of the plant. â€Å"The root† is buried in the soil or ground, so it is invisible. However, â€Å"the root† greatly influences its visible part. This illustrates Daoist’s â€Å"autopoiesis,† self-generating concept well, which differs a lot from the Western philosophical concept â€Å"arche,† which is stated or recognized as â€Å"the God. † ?. Comparative Epistemology A. Hellenistic-Prescriptive theoretical knowledge In Western tradition, most of philosophers think there is one principle or one God and things happen from it. And the mind is separable part from the body. One of the examples is Plato. Plato’s dualism is that there are the realm of form and the imperial world. The body belongs to the imperial world and the world is constantly changing. And what we sense by the body is limited, and the Empirical world is not real. The true world is the realm of the form, and the mind belongs to the world. Plato argues that the â€Å"knowledge† continuously exists and must be justified conviction. However, the Empirical world that we belong to is contentiously changing, and there is no unchanging thing in the world. That is why there is no thing from which we can get â€Å"knowledge† in the Empirical world, so we cannot get â€Å"knowledge† by our own senses. The unchanging things exist in the realm of the form, and we cannot reach the world by using our senses. So we need to use our mind to get â€Å"knowledge†. Not all of Western philosophers claim like that, but most of philosophers claim that the truth does not exist in the world where we live today. This concept greatly influences Christianity or other religions that have the one God. In Christianity, there is one God named â€Å"Jesus Christ†, and he is the reason why things happen or why we live. People pray to seek â€Å"knowledge† that exists in the world where we are not living. That is, we cannot get the â€Å"knowledge† about it in the world where we are living, and we need to get it from the other world to know the essence of the things. B. Chinese philosophy-Prescriptive practical On the other hand, there is no the one God in Chinese philosophy. In China, the war occurred constantly, and Chinese dynasty changed over time, so people did not come to rely on one thing. This influenced the Chinese philosopher. Instead of one god or one principle, Chinese philosophers think that the world creates itself and that the world is constituted by the combination of determinacy and indeterminacy, and spontaneous, dynamic changing is the universal principle of the world. In Western tradition, the philosophers try to attribute many phenomenons to the one reason. However, Chinese philosophers think that each thing is â€Å"self-so† creativity, self-generating, and spontaneous. For Chinese philosophy, the Nature is very important, and in Daoism it is important not to try to force thing. That is why there is the concepts in Daoism; wu wei(without intentional action), wu si(without deliberate thought), wu si(without selfish interesting), wu ji(without self-awareness), wu zhi(without knowledge), wu xin(without heart-and-mind). Daoists claim that when you are thinking something, the world is also changing at the same time, so you are missing something. That is why it is important for Daoism to stop thinking by your head, get out of the world of your head, look around the world, and take action. The most important thing for Daoism is that we ought to take action as a part of the world. ?. Conclusion There have been so many philosophers through the history, and each of philosophy has been developed around the world. And how people think about the world is different, depending on the philosophy. Of many philosophies, the significant different philosophies are the Western and Chinese philosophy. In the Western philosophy, the philosophers try to attribute everything to the one principle or the one God. On the other hand, there is no principle, and the philosophers have recognized the world as self-generating process, and the world is the source of itself without no exact start and end point. This thought influences religion and how people think about the world. Around the world, many wars related to religion occur today. The difference between the religions is just what ancient people developed, so it is important to try to understand the difference in today’s world. Reference. Pecorino, Philip, Ph. D. â€Å"Chapter 6 : The Mind-Body Problem Section 3: DUALISM. † Introduction To Philosophy an Online Textbook. Queensborough Community College, CUNY, n. d. Web. 4 Dec 2013. . Deutsch, Eliot. Introduction to World Philosophies. 1st ed. 509. New Jersey: A Pearson Education Company, 1997. Ex-255-256. Print. Deutsch, Eliot. Introduction to World Philosophies. 1st ed. 509. New Jersey: A Pearson Education Company, 1997. Ex-469. Print. Cohen, Marc. â€Å"The Allegory of the Cave. † Philosophy 320 History of Ancient Philosophy. University of Washington, 07 11 2013. Web. 4 Dec 2013. .

Green Chemistry Essay

Chemo-enzymatic synthesis of optically pure rivastigmine intermediate using alcohol dehydrogenase from baker’s yeast. Authors: Madhuresh K. Sethi? , Somashekar R. Bhandya? , Anish Kumar, Nagaraj Maddur, Rohit Shukla,V. S. N. Jayalakshmi Mittapalli Published: Journal of Molecular Catalysis B: Enzymatic 91 (2013) 87– 92 Paper 2 : Asymmetric synthesis of an enantiomerically pure rivastigmine intermediate using ketoreductase Authors : Madhuresh K. Sethi, Somashekar R. Bhandya, Nagaraj Maddur,  Rohit  Shukla, Anish Kumar, V. S. N. Jayalakshmi Mittapalli Published: Tetrahedron: Asymmetry,  Volume 24, Issue 7,  15 April 2013,  Pages 374-379 ON JOB EXPERIENCE IN REGULATORY AFFAIRS Organization: Intertech Labs, Hyderabad Guide: T. Raja Rao * Successfully completed course in Drug Regulatory Affairs (September 2010 – October 2011) * Gained experience of compiling , reviewing & filing of Technical Dossiers (DMF, EDMF, ANDA) * Performed Post Regulatory Audits as a part of training program * ICH Guidelines Marketing authorization in Europe(Mutual recognition procedure, Centralized procedure &Decentralized procedure) EDUCATIONAL QUALIFICATIONS| Year| Course| Institute| University/Board| Aggregate| 2008-10| M. Pharmacy| University Institute of Pharmaceutical Sciences| Panjab University| 67%| 2004-08| B. Pharmacy| University Institute of Pharmaceutical Sciences| Panjab University| 64%| 2002| 10+2| City Montessori School, Lucknow| ISC| 75%| 2000| 10th standard| City Montessori School, Lucknow| ICSE| 82 %| ACADEMIC ACHIEVEMENTS * Ranked 2nd in M. Pharmacy in Pharma Chemistry Section * Scored 93. 99 percentile in GATE , 2008 * Placement cell representative , UIPS (2008- 2010) * Delegate in CHASCON 2009, IPC 2008 EXTRA CURRICULAR ACHIEVEMENTS * Winner Intra Department Football Match – 2007 * 1st Runners up , Intra Department Cricket Match – 2005 * 2nd Prize , Intra Department Chess Competition – 2005 COMPUTER PROFICIENCY * Operating System: Microsoft XP, Vista & Windows 7. Application software: MS Office, MS excel MS access & PowerPoint. * Proficiency in handling various computing software and packages including effective usage of Pub Med, Medline, Sci Finder and other research search engines. STRENGTHS * Strong Academic Orientation * Organized, Systematic & Always looking for Perfection in my work HOBBIES * Surfing the net as a means for exchanging thoughts and views and with the aim of networking. * Watching movies & playing chess REFERENCES * On request

Final paper Essay Example | Topics and Well Written Essays - 2000 words - 1

Final paper - Essay Example Those behind these acts claim that they are doing this to protect the interest of Islam. This has certainly not helped the cause of Islam. In fact this has made the life difficult for many of those following the religion. Incidents when leading personalities from many countries having Muslim names are harassed in the name of frisking at airports in US, UK and Germany highlight the kind of suspicions that has arisen in the western nations about those following Islam. Investigating agencies have been pointing towards organizations like Al-Qaeda and people like Osama Bin Laden for carrying out major terror acts happening around the world. Such revelations have in a sense brought the western nations on a collision course with Islam in general. But it is equally true that majority of the Muslims around the world not only denounce such heinous acts, but they are the worst sufferers. Therefore, why is it that the despite being at the receiving end the followers of Islam get labeled as intol erant. Therefore, it is a critical period for the Islamic world and they need to take on the menace head on in order to bring about some pragmatic changes in the attitude of the Western nations towards Islam. Some such steps could be; i. Gradually dissociating themselves from terror related groups: As of now the general impression is that, even if not many nations are supporting the terror groups, they are not coming out openly against those groups either. The silence could be because of some antipathy towards some of the policies of the western nations, but it is indirectly helping the cause of the terrorist outfits. This certainly cannot be done overnight and it has to be a gradual process, because in case of sudden announcements, those making such announcements will themselves become targets of terror outfits. ii. The terrorist activities cannot be carried

Political Multimedia Assignments Essay Example | Topics and Well Written Essays - 1750 words

Political Multimedia Assignments - Essay Example Although they use the fanatical right as a way of gaining the support of people who are not within the upper 1% in wealth in the nation, the Republican Party still stands on its original platform of less regulation and more freedoms and rights for corporations. This is in direct conflict with the needs of workers, but workers have flocked to the Republican Party due to fear of losing the rights they have or in support of radical ideas about the world concerning religion, guns, or abortion. This is corporate greed at its worst. What has happened as a consequence is that the irrational and unreasonable now have a voice and official support. Silver is placing the consequences of such hard-lined campaigning for ‘sides’ into context in order to show that people are becoming more about their political party than about the issues due to the polarization. Silver suggests that the Republican Party has now created a sort of vacuum in which they now must continue their fanaticism i n order to maintain those they convinced to join them. Instead of being able to come closer to the middle, in order to keep those they convinced to join they are stuck well over to the right. ... The Republican Party remade itself to be the party of the people through giving voice to radicalized beliefs. Now they are stuck with it. The Story of Stuff â€Å"The Story of Stuff† shows how little control consumers have in what they buy and what they are exposed to from their stuff. It also shows the blatant manipulation that all consumers experience. Most consumers know they are being manipulated, but still play into consuming more and more goods. The need to consume resources and then throw them away, according to the video, was designed. What does that mean for American society? It seems that it started with 19th century colonialism where one state felt they had the right to ‘claim’ another state and consume its resources. It could go back to the time of exploration where lands such as the Americas were claimed for Spain or England, but those times still allowed for the natural consumption of resources. Although, the destruction of buffalo for their hides by those European Ancestors who sought to claim the American West who then left the meat to rot in large fields of blood might be seen as one of the beginnings of this problem. The European American habit of conquering and stripping a land from its indigenous people, leaving them without the means to sustain their cultures as they once were is at the heart of this problem, and it began with those who claimed the right to colonialism. According to the video, Americans literally consumer 99% of what they buy which will be disposed of by the end of its first year of use. This is literal consumption. Every week as the trash is thrown out is seems that there are more and more quantities of

Waste Management (Firm Analysis) Essay Example | Topics and Well Written Essays - 2500 words

Waste Management (Firm Analysis) - Essay Example nvironment protection and regarded as an interface between the production, distribution and consumption of goods on the one hand, and soil, groundwater, air and climate on the other. Hence, it is an essential collaborator in the perspective of sustainable development. In the current scenario, industrialized nations are busy enhancing their regulatory frameworks and waste management infrastructure. As it is, the industry deals with extensively rising environmental and legal standards, best practices and the need for greater efficiency, quality management and occupational health aspects. Apparently, with the diversity and intricacy of products and accordingly of wastes, byproducts, and residues, there is no single solution to the waste treatment demands of today. A suitable combination of technologies is necessary in order to meet and respond to the many technical, ecological and economic requirements of integrated waste management on a regional level. As long as industry and consumers produce waste, an infrastructure is needed for their proper treatment and detoxification and for the secure and continuing disposal of residues (Hunt, 1990). The idea of producer’s responsibility was realized by swinging or reallocating the financial burden for the appropriate treatment or recycling of end-of-life products to manufacturers. This move established a new line of communication between the environmental sector and the manufacturing segments of society. In this scheme, waste managers convey information concerning designs for recycling and the design for disposal upstream to producers and manufacturers, thereby advocating the cause of the environment’s capacities and environmental constraints (Deyle, 1990). Today, the waste management industry is highly conscious and responsive of the significance of social aspects. These include, among others, the siting of facilities and introduction of novel collection schemes, educating consumers, training workers and staff,

Civil War and Reconstruction Essay Example | Topics and Well Written Essays - 750 words

Civil War and Reconstruction - Essay Example Consequently historical events like Reconstruction, Wade-Davis Bill, Black Codes, Segregation, Jim Crow laws, the 13th Amendment to the 15th Amendment to the Constitution etc were some steps towards the construction of a race-blind society. The next mentionable event in the Reconstruction era was the Wade-Davis Bill in 1864. The racial Segregation and the Jim Crow laws, in a single phrase the â€Å"separate policy† of the south was essentially the South’s reaction to the 13th, 14th and the 15th constitutional Amendments during the Reconstruction in the post Civil War Period. Reconstruction’s primary goals were to establish the Black rights by withering out Slavery and to reintegrate the South with the nation. The Reconstruction started with President Lincoln’s affirmative actions for a race-blind, equal and reunited America. While Lincoln followed a more moderate course to establish black people’s right and to reunite the South, the Radical Republic ans â€Å"opposed it on the ground that Lincoln reconstruction plan had freed the slaves without paying much attention to establishing their socio-political, economic and other rights† (Stampp, 1956, p. 78). By passing the Wade-Davis Bill in 1864 Republican dominated Congress declare that Southern States should be run by military governors and, Secession and Slavery would be outlawed with the consent of the fifty percent of a state’s voters. ... Both theoretically and legally by the 13th Amendment of the Constitution slavery was outlawed; empowered by the 14th Amendment, people of colors could enter into contracts, business, ownership, etc and by the 15th Amendment they earned the right to vote. But the reality was totally different from what the Northerners expected from the Amendments and their enactment, as Gerald Early says in this regard, â€Å"white southerners, inspired by the North's old Black Codes, instituted their own version†¦..in response to the passage of the 13th Amendment to the Constitution†¦Ã¢â‚¬  (Early, 2011, p. 2) While before the 13th Amendment in the pre-Civil War period, the Southerners enjoyed unchallenged mastery over the Blacks and exploited the black labor to sustain the South’s plantation and other agriculture based economy, after the constitutional abolition of slavery the South sought to generate unofficial laws limiting the blacks’ civil rights, during the Johnson Pre sidency, with a view to manipulate black labor evading the Constitutional restrictions. Indeed the Southerners’ strategy was to retain psychological inferiority of the Blacks so that the cheap black labor could easily be manipulated. Since slavery became an indispensable part of the colonizer’s economy and became socio-politically integrated into the early American society, it began to shift its basis from war to color after the 13th Amendment. Josef Healey (2010) says that â€Å"blackness† itself as an ideology was critical for the exploitation of the labor of the African blacks in early America, and it â€Å"provided the very source of whiteness and the heart of racism† (Healey, 2010, p. 288). This master-slave association greatly

Key learning Essay Example | Topics and Well Written Essays - 500 words

Key learning - Essay Example It is important to learn that determination makes individuals to aspire for a better performance in the next stage. Support from others reassures people that they are not alone in the current circumstance and gives them strength to move on (Lewis 47). This is a key learning point because the neutral zone acts as a redefining moment in the life of an individual. This understanding can an individual learn that difficulties are temporary and that they will go away once he or she succeeds out of this zone (Lewis 47). This is an important learning point because it underscores effectiveness as an indicator of good leadership. This draws from the role of a leader in coordinating the activities of the team and providing direction (Lewis 48). It is crucial to learn that fairness and honesty creates a trusting environment and leads to success because it wins the support of the team towards a leader’s plans. This way, the leader does not strain mobilizing group members for action (Lewis 49). Learning not to overact to resistance and opposition is important because it help to remain objective. This way, a change leader gets time to plan how to counter the resistance in a way that does not scare away the support of the team (Lewis 51). It is important to learn that low trust makes individuals fear for the welfare and this makes them not embrace the change thus disrupting the success of the transition. The change leader needs to convince the team that their welfare is his or her concern (Lewis 52). There is need for change leaders to persuade the team of the efficacy of the intended change plan inviting their participation in the change process. A compelling vision implores people to be proactive in realizing the goal of the change process (Lewis 54). Change process needs leadership and coordination in order to remain harmonious and consistent.

The Company Novartis Essay Example | Topics and Well Written Essays - 1000 words

The Company Novartis - Essay Example Therefore, Novartis is famous for the Central Nervous System Segment. Instead of concentrating the attention mostly on medicines, which can be sold in large markets, Novartis’ experts are analyzing rare illnesses with the purpose of using the findings also for common diseases. For instance, Novartis created medicine to treat auto-inflammatory disorder that can be met with patients very seldom, however it was proved that this medicine can be also successfully applied to treat a very widespread form of arthritis. So, the company’s method is oriented on satisfying the needs of many patients with different diseases at once. International factor The Central Nervous System Segment of the Company is popular in 140 countries. For a good brand development, it is not enough to make an innovation but also to use the world-accepted resources, make trials on the global level. The Central Nervous System Segment of Novartis gains a new experience through successful cooperation with in ternational partners who also have a strong desire to make innovations and investigations of new drugs invented to treat patients all over the world (Novartis Global at www.novartis.com). The company Novartis also created a special Biocamp – a place where students and young scientists from all the countries of the world can meet and share their knowledge. Such meetings are very useful for innovative developments in this sector in particular (Home 46). Political factors Every international business presupposes systematic evaluation of different risks connected with political environment of different countries. Each country has its own political system, its own rules and its own strategy. Politics and economics are closely connected and the uncertain reforms affect the activity of the international companies much. Political environment changes always influence the company’s activity, so Novartis needs to adjust to these changes and make good forecasts to avoid difficulti es and losses (Novartis Global at www.novartis.com). In the face of global political changes, the Central Nervous System Segment of Novartis is focused on different relevant issues and aspects of their current activities, which can often exceed the limits of their direct activities. Social factors The main goal of Central Nervous System Segment of is to develop medical innovations for a total eradication of nervous diseases among people all over the world. Thus, the activity of the organization is very important for the society. Novartis create new healthcare products aiming at finding the solutions to the unsolved issues in modern medicine. The main goal is to gain the trust of the patients and consumers. Thus business should be reliable and principled. Joseph Jimenez, Chief Executive Officer, Novartis said: â€Å"We apply our expertise in science and innovation to society’s biggest health challenges. We take our role in improving health seriously and focus on areas where w e can lead and make a significant impact.† The company understands that people want it to find solutions to the most difficult problems in modern medicine. To improve this segment and all other aspects of their activities, people should take into account the needs for the company satisfies the needs of more the 1 billion people every year but the world has 7 billion and all of them need medicines (Novartis Globa

Animism and Personification Term Paper Example | Topics and Well Written Essays - 750 words

Animism and Personification - Term Paper Example These religions are given the term primal because of the animistic belief embodied in it (Super and Turley, p.18). Primal religions have a strong belief in animism and personification. Primal religions believe in the connection of all existence, whether it be humans, animals or even nature. In fact, nature is on the focal points of primal religion. Each being, each place, each object was reasoned to have a spirit, which is called anima. In such a manner, everything has a purpose, a reason for its existence. This is closely related to how people have lived centuries ago, in the time where hunting and gathering were the primary means of living. In primal religions, the distinction between good and bad is associated with misfortune and fortune. Long ago, people do not have the technology and knowledge that we have today that can explain illness, death and suffering. Although primal religions believe in a greater or supreme being, it also brings forth the belief in entities, deities and spirits that dwell among people and nature who can and may interfere with people’s lives when they desire to or when they are disturbed. With limited knowledge and the belief in animism and personification, the people do not have an explanation to the misfortunes they are experiencing except to use their primal religion as a way to understand their lives. With this, primal religion do not relate good and bad to natural or unnatural rather they relate good and bad to how they view their relation with the spirits and deities around them through their relation with other people and with nature. Nature has a very big impact in the way people lived. By taking care of their environment and essentially nature, people believed that they will be blessed by being given back plants, trees, fruits, crops and animals that will serve as their food, shelter and clothing. Good and bad became a distinction between taking care of the things around them versus destroying their environment. When something bad happens, such as a plague, people generally believe that they are being punished because they disturbed the balance or they believe that there was something they have done that offended the spirits, deities and other beings. With this, they try to turn things around through offerings and sacrifices, which are quite different from how we do it today. Another perspective of good and bad in the primal religion is the distinction between suffering and good fortune. When a person experiences suffering, it is related to something bad or evil. And when people, with this limited knowledge, no modern technology and with a belief in animism, look for a reason behind this suffering, they associate it with something bad or evil, which is related to the idea of the unknown. Anything that is unknown to them that causes misfortune, suffering or death is equated to bad or evil. But not all unknown is related to evil and not all known is related to good. The relation is based on their experience. For example, when there is an eclipse and something bad happens to them, like crops dying, they automatically associate this with something evil. When there is a shooting star, or in our knowledge now a meteor shower, and something good happens after it like animals migrating to their area, they automatically think that the meteor showers are something good. This association comes from the primal belief that all things are interrelated or intertwined. And this is because of the communitarian way the people of those ages lived (Sharma, p.4). The primal belief has another important characteristic, and that is the belief that people, animals and other things are held together by an ultimate nature and

Cover Note Essay Example for Free

Cover Note Essay The Relation of Science and Religion is a transcript of a talk given by Dr. Feynman at the Caltech YMCA Lunch Forum on May 2, 1956. In this age of specialization men who thoroughly know one field are often incompetent to discuss another. The great problems of the relations between one and another aspect of human activity have for this reason been discussed less and less in public. When we look at the past great debates on these subjects we feel jealous of those times, for we should have liked the excitement of such argument. The old problems, such as the relation of science and religion, are still with us, and I believe present as difficult dilemmas as ever, but they are not often publicly discussed because of the limitations of specialization. But I have been interested in this problem for a long time and would like to discuss it. In view of my very evident lack of knowledge and understanding of religion (a lack which will grow more apparent as we proceed), I will organize the discussion in this way: I will suppose that not one man but a group of men are discussing the problem, that the group consists of specialists in many fields – the various sciences, the various religions and so on – and that we are going to discuss the problem from various sides, like a panel. Each is to give his point of view, which may be molded and modified by the later discussion. Further, I imagine that someone has been chosen by lot to be the first to present his views, and I am he so chosen. I would start by presenting the panel with a problem: A young man, brought up in a religious family, studies a science, and as a result he comes to doubt – and perhaps later to disbelieve in – his fathers God. Now, this is not an isolated example; it happens time and time again. Although I have no statistics on this, I believe that many scientists – in fact, I actually believe that more than half of the scientists – really disbelieve in their fathers God; that is, they dont believe in a God in a conventional sense. Now, since the belief in a God is a central feature of religion, this problem that I have selected points up most strongly the problem of the relation of science and religion. Why does this young man come to disbelieve? The first answer we might hear is very simple: You see, he is taught by scientists, and (as I have just pointed out) they are all atheists at heart, so the evil is spread from one to another. But if you can entertain this view, I think you know less of science than I know of religion. Another answer may be that a little knowledge is dangerous; this young man has learned a little bit and thinks he knows it all, but soon he will grow out of this sophomoric sophistication and come to realize that the world is more complicated, and he will begin again to understand that there must be a God. I dont think it is necessary that he come out of it. There are many scientists – men who hope to call themselves mature – who still dont believe in God. In fact, as I would like to explain later, the answer is not that the young man thinks he knows it all – it is the exact opposite. A third answer you might get is that this young man really doesnt understand science correctly. I do not believe that science can disprove the existence of God; I think that is impossible. And if it is impossible, is not a belief in science and in a God – an ordinary God of religion — a consistent possibility? Yes, it is consistent. Despite the fact that I said that more than half of the scientists dont believe in God, many scientists do believe in both science and God, in a perfectly consistent way. But this consistency, although possible, is not easy to attain, and I would like to try to discuss two things: Why it is not easy to attain, and whether it is worth attempting to attain it. When I say believe in God, of course, it is always a puzzle – what is God? What I mean is the kind of personal God, characteristic of the western religions, to whom you pray and who has something to do with creating the universe and guiding you in morals. For the student, when he learns about science, there are two sources of difficulty in trying to weld science and religion together. The first source of difficulty is this – that it is imperative in science to doubt; it is absolutely necessary, for progress in science, to have uncertainty as a fundamental part of your inner nature. To make progress in understanding we must remain modest and allow that we do not know. Nothing is certain or proved beyond all doubt. You investigate for curiosity, because it is unknown, not because you know the answer. And as you develop more information in the sciences, it is not that you are finding out the truth, but that you are finding out that this or that is more or less likely. That is, if we investigate further, we find that the statements of science are not of what is true and what is not true, but statements of what is known to different degrees of certainty: It is very much more likely that so and so is true than that it is not true; or such and such is almost certain but there is still a little bit of doubt; or – at the other extreme – well, we really dont know. Every one of the concepts of science is on a scale graduated somewhere between, but at neither end of, absolute falsity or absolute truth. It is necessary, I believe, to accept this idea, not only for science, but also for other things; it is of great value to acknowledge ignorance. It is a fact that when we make decisions in our life we dont necessarily know that we are making them correctly; we only think that we are doing the best we can – and that is what we should do. Attitude of uncertainty I think that when we know that we actually do live in uncertainty, then we ought to admit it; it is of great value to realize that we do not know the answers to different questions. This attitude of mind – this attitude of uncertainty – is vital to the scientist, and it is this attitude of mind which the student must first acquire. It becomes a habit of thought. Once acquired, one cannot retreat from it any more. What happens, then, is that the young man begins to doubt everything because he cannot have it as absolute truth. So the question changes a little bit from Is there a God? to How sure is it that there is a God? This very subtle change is a great stroke and represents a parting of the ways between science and religion. I do not believe a real scientist can ever believe in the same way again. Although there are scientists who believe in God, I do not believe that they think of God in the same way as religious people do. If they are consistent with their science, I think that they say something like this to themselves: I am almost certain there is a God. The doubt is very small. That is quite different from saying, I know that there is a God. I do not believe that a scientist can ever obtain that view – that really religious understanding, that real knowledge that there is a God – that absolute certainty which religious people have. Of course this process of doubt does not always start by attacking the question of the existence of God. Usually special tenets, such as the question of an afterlife, or details of the religious doctrine, such as details of Christs life, come under scrutiny first. It is more interesting, however, to go right into the central problem in a frank way, and to discuss the more extreme view which doubts the existence of God. Once the question has been removed from the absolute, and gets to sliding on the scale of uncertainty, it may end up in very different positions. In many cases it comes out very close to being certain. But on the other hand, for some, the net result of close scrutiny of the theory his father held of God may be the claim that it is almost certainly wrong. Belief in God – and the facts of science That brings us to the second difficulty our student has in trying to weld science and religion: Why does it often end up that the belief in God – at least, the God of the religious type – is considered to be very unreasonable, very unlikely? I think that the answer has to do with the scientific things – the facts or partial facts – that the man learns. For instance, the size of the universe is very impressive, with us on a tiny particle whirling around the sun, among a hundred thousand million suns in this galaxy, itself among a billion galaxies. Again, there is the close relation of biological man to the animals, and of one form of life to another. Man is a latecomer in a vast evolving drama; can the rest be but a scaffolding for his creation? Yet again, there are the atoms of which all appears to be constructed, following immutable laws. Nothing can escape it; the stars are made of the same stuff, and the animals are made of the same stuff, but in such complexity as to mysteriously appear alive – like man himself. It is a great adventure to contemplate the universe beyond man, to think of what it means without man – as it was for the great part of its long history, and as it is in the great majority of places. When this objective view is finally attained, and the mystery and majesty of matter are appreciated, to then turn the objective eye back on man viewed as matter, to see life as part of the universal mystery of greatest depth, is to sense an experience which is rarely described. It usually ends in laughter, delight in the futility of trying to understand. These scientific views end in awe and mystery, lost at the edge in uncertainty, but they appear to be so deep and so impressive that the theory that it is all arranged simply as a stage for God to watch mans struggle for good and evil seems to be inadequate. So let us suppose that this is the case of our particular student, and the conviction grows so that he believes that individual prayer, for example, is not heard. (I am not trying to disprove the reality of God; I am trying to give you some idea of – some sympathy for – the reasons why many come to think that prayer is meaningless. ) Of course, as a result of this doubt, the pattern of doubting is turned next to ethical problems, because, in the religion which he learned, moral problems were connected with the word of God, and if the God doesnt exist, what is his word? But rather surprisingly, I think, the moral problems ultimately come out relatively unscathed; at first perhaps the student may decide that a few little things were wrong, but he often reverses his opinion later, and ends with no fundamentally different moral view. There seems to be a kind of independence in these ideas. In the end, it is possible to doubt the divinity of Christ, and yet to believe firmly that it is a good thing to do unto your neighbor as you would have him do unto you. It is possible to have both these views at the same time; and I would say that I hope you will find that my atheistic scientific colleagues often carry themselves well in society. Communism and the scientific viewpoint I would like to remark, in passing, since the word atheism is so closely connected with communism, that the communist views are the antithesis of the scientific, in the sense that in communism the answers are given to all the questions – political questions as well as moral ones – without discussion and without doubt. The scientific viewpoint is the exact opposite of this; that is, all questions must be doubted and discussed; we must argue everything out – observe things, check them, and so change them. The democratic government is much closer to this idea, because there is discussion and a chance of modification. One doesnt launch the ship in a definite direction. It is true that if you have a tyranny of ideas, so that you know exactly what has to be true, you act very decisively, and it looks good – for a while. But soon the ship is heading in the wrong direction, and no one can modify the direction any more. So the uncertainties of life in a democracy are, I think, much more consistent with science. Although science makes some impact on many religious ideas, it does not affect the moral content. Religion has many aspects; it answers all kinds of questions. First, for example, it answers questions about what things are, where they come from, what man is, what God is – the properties of God, and so on. Let me call this the metaphysical aspect of religion. It also tells us another thing – how to behave. Leave out of this the idea of how to behave in certain ceremonies, and what rites to perform; I mean it tells us how to behave in life in general, in a moral way. It gives answers to moral questions; it gives a moral and ethical code. Let me call this the ethical aspect of religion. Now, we know that, even with moral values granted, human beings are very weak; they must be reminded of the moral values in order that they may be able to follow their consciences. It is not simply a matter of having a right conscience; it is also a question of maintaining strength to do what you know is right. And it is necessary that religion give strength and comfort and the inspiration to follow these moral views. This is the inspirational aspect of religion. It gives inspiration not only for moral conduct – it gives inspiration for the arts and for all kinds of great thoughts and actions as well. Interconnections These three aspects of religion are interconnected, and it is generally felt, in view of this close integration of ideas, that to attack one feature of the system is to attack the whole structure. The three aspects are connected more or less as follows: The moral aspect, the moral code, is the word of God – which involves us in a metaphysical question. Then the inspiration comes because one is working the will of God; one is for God; partly one feels that one is with God. And this is a great inspiration because it brings ones actions in contact with the universe at large. So these three things are very well interconnected. The difficulty is this: that science occasionally conflicts with the first of the three categories – the metaphysical aspect of religion. For instance, in the past there was an argument about whether the earth was the center of the universe – whether the earth moved around the sun or stayed still. The result of all this was a terrible strife and difficulty, but it was finally resolved – with religion retreating in this particular case. More recently there was a conflict over the question of whether man has animal ancestry. The result in many of these situations is a retreat of the religious metaphysical view, but nevertheless, there is no collapse of the religion. And further, there seems to be no appreciable or fundamental change in the moral view. After all, the earth moves around the sun – isnt it best to torn the other cheek? Does it make any difference whether the earth is standing still or moving around the son? We can expect conflict again. Science is developing and new things will be found out which will he in disagreement with the presentday metaphysical theory of certain religions. In fact, even with all the past retreats of religion, there is still real conflict for particular individuals when they learn about the science and they have heard about the religion. The thing has not been integrated very well; there are real conflicts here – and yet morals are not affected. As a matter of fact, the conflict is doubly difficult in this metaphysical region. Firstly, the facts may be in conflict, but even if the facts were not in conflict, the attitude is different. The spirit of uncertainty in science is an attitude toward the metaphysical questions that is quite different from the certainty and faith that is demanded in religion. There is definitely a conflict, I believe – both in fact and in spirit – over the metaphysical aspects of religion. In my opinion, it is not possible for religion to find a set of metaphysical ideas which will be guaranteed not to get into conflicts with an everadvancing and alwayschanging science which is going into an unknown. We dont know how to answer the questions; it is impossible to find an answer which someday will not be found to be wrong. The difficulty arises because science and religion are both trying to answer questions in the same realm here. Science and moral questions On the other hand, I dont believe that a real conflict with science will arise in the ethical aspect, because I believe that moral questions are outside of the scientific realm. Let me give three or four arguments to show why I believe this. In the first place, there have been conflicts in the past between the scientific and the religious view about the metaphysical aspect and, nevertheless, the older moral views did not collapse, did not change. Second, there are good men who practice Christian ethics and who do not believe in the divinity of Christ. They find themselves in no inconsistency here. Thirdly, although I believe that from time to time scientific evidence is found which may be partially interpreted as giving some evidence of some particular aspect of the life of Christ, for example, or of other religious metaphysical ideas, it seems to me that there is no scientific evidence bearing on the golden rule. It seems to me that that is somehow different. Now, lets see if I can make a little philosophical explanation as to why it is different – how science cannot affect the fundamental basis of morals. The typical human problem, and one whose answer religion aims to supply, is always of the following form: Should I do this? Should we do this? Should the government do this? To answer this question we can resolve it into two parts: First — If I do this, what will happen? – and second – Do I want that to happen? What would come of it of value – of good? Now a question of the form: If I do this, what will happen?is strictly scientific. As a matter of fact, science can be defined as a method for, and a body of information obtained by, trying to answer only questions which can be put into the form: If I do this, what will happen? The technique of it, fundamentally, is: Try it and see. Then you put together a large amount of information from such experiences. All scientists will agree that a question – any question, philosophical or other – which cannot be put into the form that can be tested by experiment (or, in simple terms, that cannot be put into the form: If I do this, what will happen?) is not a scientific question; it is outside the realm of science. I claim that whether you want something to happen or not – what value there is in the result, and how you judge the value of the result (which is the other end of the question: Should I do this? ) – must lie outside of science because it is not a question that you can answer only by knowing what happens; you still have to judge what happens – in a moral way. So, for this theoretical reason I think that there is a complete consistency between the moral view – or the ethical aspect of religion – and scientific information. Turning to the third aspect of religion – the inspirational aspect – brings me to the central question that I would like to present to this imaginary panel. The source of inspiration today – for strength and for comfort – in any religion is very closely knit with the metaphysical aspect; that is, the inspiration comes from working for God, for obeying his will, feeling one with God. Emotional ties to the moral code – based in this manner – begin to be severely weakened when doubt, even a small amount of doubt, is expressed as to the existence of God; so when the belief in God becomes uncertain, this particular method of obtaining inspiration fails. I dont know the answer to this central problem – the problem of maintaining the real value of religion, as a source of strength and of courage to most men, while, at the same time, not requiring an absolute faith in the metaphysical aspects. The heritages of Western civilization Western civilization, it seems to me, stands by two great heritages. One is the scientific spirit of adventure – the adventure into the unknown, an unknown which must be recognized as being unknown in order to be explored; the demand that the unanswerable mysteries of the universe remain unanswered; the attitude that all is uncertain; to summarize it – the humility of the intellect. The other great heritage is Christian ethics – the basis of action on love, the brotherhood of all men, the value of the individual – the humility of the spirit. These two heritages are logically, thoroughly consistent. But logic is not all; one needs ones heart to follow an idea. If people are going back to religion, what are they going back to? Is the modern church a place to give comfort to a man who doubts Godmore, one who disbelieves in God? Is the modern church a place to give comfort and encouragement to the value of such doubts? So far, have we not drawn strength and comfort to maintain the one or the other of these consistent heritages in a way which attacks the values of the other? Is this unavoidable? How can we draw inspiration to support these two pillars of western civilization so that they may stand together in full vigor, mutually unafraid? Is this not the central problem of our time? I put it up to the panel for discussion.

Euro Disney Essay Example for Free

Euro Disney Essay Despite a long story of success in the past, Euro Disney failed to anticipate demand accurately for their services. The company failed to recognize the frugality and price consciousness of the European customers which had a direct impact on the spending Patterns of the consumers. They assumed Europeans to follow the same pattern as the Americans however this was not the case hence it suffered huge losses. Cultural differences can lower the impact of a certain service and will lead to lower projected revenues. Euro Disney had visitors from all over Europe which spoke different languages, they shared different culture and history compared to American. It was important to integrate it into the theme park before hand. These differences adversely affected the company; alcohol wasn’t served in the park in a country where wine was a norm with food, inability to realize Europeans peak leisure days and serving them breakfast. A better analysis before hand and a president from the local environment initially would have been more familiar with the local environment would have led to increase in revenue. It was very important to be familiar with the mindset of the people while working with those belonging to different culture in order to maintain smooth working environment. The French unlike the Americans were sensitive and touchy people. To foster good will with them one has to incorporate them in one’s decisions and discussions and not just dominate them because this will infuriate them and alienate them and their support and cooperation. The French don’t like bossy attitude coming towards them hence one should be modest in dealing with them. The Tokyo Disney turned out to be a great success, way more than the expectations. The number of visitors was high with large revues and profits. Japanese were adaptable and flexible lot they welcomed American culture in the theme park from food to entertainment whereas the Europeans were reluctant to adopt the American style initially due to which Disney had to face many problems of cultural diversity in Euro Disney. Euro Disney was located at an ideal place as it was close to Paris, Paris being Europe’s largest tourist destination. The problem was not with the location but with other factors such as skimming pricing strategy for the price sensitive Europeans proved to be a failure, recession in the economy, failure to anticipate demand and cultural differences and apart from these operational inefficiencies and mismanagement. Location would not have made these factors better hence it would not have done better if located anywhere outside Paris too. Mickey Mouse is one of the greatest characters of Walt Disney and has a long history of success with the company. It is an icon of American culture; Mickey Mouse has always been one of the attractions at the Disney theme park. Unlike other American theme parks Euro Disney was criticized among the French for being too American and caused a clash, resentment and low turnover from them as they believed keeping French culture aside American culture was being imposed on them. Hence in order to counter the ethnocentric views Disney had to incorporate the French culture into the American Disney image for the liking of the Europeans. In order to make an impact on the Europeans, Disney was required to make a campaign that would have focused on French names and terminology, such as names of the rides and the restaurant menus, the French wanted their culture opposed to the American as it did not   tune in   with their own. Similarly the European Walt Disney studios should focus on French movies and people as a means of entertainment. It should be positioned as a theme park that as a perfect vacation resort and not the American resort in particular. This positioning can be done by engaging tourist guides, bus drivers and travel agents into the marketing campaign and providing them incentives to promote the promotional campaign of the company. Though Disney entered Europe with high hopes and confidence however it had to face losses due to the many mistakes it made in planning and launching the theme park. One such mistake was the price skimming strategy, Disney expected the demand for its park to be inelastic and hence it could have gained high revenues. However, raising admission prices would have added fuel to the situation because the turnover from the French people was already low, their low spending patterns, frugality, and economic recession would have discouraged people from visiting the park as prices were already considered to be very high and would have lead to further losses for Euro Disney. References Jiffy Notes. (n.d.). EURO DISNEY S.C.A. Retrieved May 21, 2010, from JiffyNotes.com: http://www.jiffynotes.com/a_study_guides/book_notes_add/emmc_0001_0001_0/emmc_0001_0001_0_00102.html

Analysis of Response Surface Methodology (RSM)

Analysis of Response Surface Methodology (RSM) 1.3 DESIGN OF EXPERIMENTS 34, 35 Trans-Pacific Partnership economic framework agreement has clearly defined that many studies must be conducted to develop a formulation. Design of experiments (DOE) has proven to be an effective tool for formulation scientists throughout the many stages of the formulation process. At every step of formulation development, DOE can aid in making intelligent decisions. These steps include excipient compatibility studies, process feasibility studies, formulation optimization, process optimization, scale-up and manufacturing process characterization. Lastly, the product and manufacturing process must be validated before it is on the market. The word optimize is defined as, making as perfect, effective or functional as possible. Optimization may be interpreted as to find out the value of controllable independent variable, that gives the most desired value of dependent variables. The application of formulation optimization techniques is relatively new to the practice of pharmacy when used intelligently, with the common sense, these â€Å"statistical† methods will broaden the perspective of the formulation process. At the Preformulation stage, before any experiment is conducted certain problem arises, it is often not known before hand which variable will significantly influence the response. Screening designs and ANOVA helps to solve this problem. A second serious complication may arise with new excipients and new process factor, for which qualitative or quantitative effects are not known and are unpredictable. The following questions must be answered before choosing any design of experiment. The third complication is that formulated products, in particular dosage form has to confirm to several requirements, very often competing. The formulator has to trade off objectives and choose a compromise. A fourth problem is the lack of insight` to perform an adequate optimization studies. Above all in the performance of an optimization study, the formulation development scientist can also be a factor as personal variation. 1.3.1 Terms used in Design of experiments Variables These are the measurements, values, which are characteristics of the data. There are two types of variables; dependent variables and independent variables. Independent variables(X) are set in advance, which are not influenced by any other values e.g., Lubricants concentration, drug to polymer ratio, etc. Dependent variables(Y) are the outcome variables, influenced by the independent variables e.g., hardness, dissolution rate, etc. Factor Factor is an assigned variable such as concentration, temperature, lubricant agent, drug to polymer ratio, polymer to polymer ratio or polymer grade. A factor can be qualitative or quantitative. A quantitative factor has a numerical value to it for example, concentration (1%, 2%†¦ so on), drug to polymer ratio (1:1, 1:2†¦etc). Qualitative factors are the factors, which are not numerical value, for example, the polymer grade, humidity condition, type of equipment, etc. these are discrete in nature. Levels The levels of a factor are the values or designation assigned to the factor. For e.g. in concentration (factor) 1 % will be one level, while 2% will be another level. Two different plasticizers are levels for grade factor. Usually levels are indicated as low, middle or high level. Normally for ease of calculation the numeric and discrete levels are converted to –1 (low level) and +1 (high level).The general formula for this conversion is Where ‘X’ is the numeric value Response Response is mostly interpreted as the outcome of an experiment. It is the effect, which we are going to evaluate i.e. Disintegration time, duration of buoyancy, etc. Effect The effect of a factor is the change in response caused by varying the levels of the factor. This describes the relationship between various factors and levels. Interaction Interaction is also similar to effect, which gives the overall effect of two or more variables (factors) on a response. For example, the combined effect of lubricants (factor) and glidants (factor) on hardness (response) of a tablet. In the trial and error method, a lot of formulations have to be prepared to get a conclusion, which involves lots of money, time and energy. These can be minimized by the use of optimization technique. 1.3.2 Optimization Process Generally optimization process involves the following steps. Based on the previous knowledge or experience or from literature, the independent variables are determined and set in the beginning. Selection of a suitable model, based on the results of the factor, screening is done. The experiments are designed and conducted. The responses are analyzed by ANOVA, test on lack of fit, to get an empirical mathematical model for each individual response. The responses are screened, by using multiple criteria to get the values of independent variables. Experimental Design Experimental design is a statistical design that prescribes or advises a set of combination of variables. The number and layout of these design points within the experimental region, depends on the number of effects that must be estimated. Depending on the number of factors, their levels, possible interactions and order of the model, various experimental designs are chosen. Each experiment can be represented as a point within the experimental domain, the point being defined by its co-ordinate (the value given to the variables) in the space. 1.3.3 Response Surface Methodology Response surface methodology (RSM) is an experimental strategy that was developed in the 1950’s36. RSM is comprised of a group of mathematical and statistical techniques that are based on fitting experimental data generated from studies established using an experimental design, to empirical models and that are subsequently used to define a relationship between the responses observed and the independent input variables37, 38. RSM is able to define the effect of independent variables alone and in combination with the manufacturing processes under investigation. A typical RSM study begins initially with the definition of a problem to be investigated and involves establishing which variables and associated responses are to be studied, monitored, and measured and how these will be measured. A summary of the subsequent RSM approach includes36 Performance of the relevant DOE. Estimation of the coefficient in the relevant response surface equation. Checking of the adequacy of the equation to describe the fit. Studying the response surface to identify and evaluate the region(s) of interest. The term RSM originates from the graphical perspective generated after fitness of the mathematical model has been established 37, 38 with a graphical representation of the data presented primarily as a three-dimensional (3D) image and/or as contour plots39. The relationship between a response and an input variable can be described by Equation 1.1 y= f(x1, x2, x3†¦xn) +ÃŽ µ Where, y = relevant response f = unknown function of a response x1, x2,..xn = independent variables n= number of independent variables ÃŽ µ = statistical error that represents other sources of variability not accounted for by f Contour plot can be described as: i. Mound-shaped that has elliptical contours with a stationary point at the position of a maximum response. ii. Saddle-shaped that has a hyperbolic system of contours with a stationary point that is neither a maximum nor minimum point. iii. Constant (stationary) ridge response surface in which the contours are presented as concentric elongated ellipses with a stationary point in the region of the design region. iv. A rising (or falling) ridge response surface with a stationary point that is outside the design region 39. The stationary point is a combination of design variables where the surface presents as either a maximum and/or a minimum in all directions. If the stationary point is a maximum in one direction and minimum in another direction, the stationary point is termed a saddle point. When the surface is curved in one direction but is fairly constant and this is considered a ridge response 40. By plotting a response, y, against one or two input variables a surface, known as the response surface can be generated in two or three dimensions. In general the form of the function, f, is unknown and may be very complicated depending on the effect of the input variables on the response. Therefore RSM aims at approximating f by use of a suitable, ordered polynomial equation in some region(s) of the values for the independent process variables41. The mathematical or polynomial equations that describe the relationship(s) between the independent and dependent variables may be first, second or third order, depending on how the output variables or responses react to changes in the input variables. If the response is a linear function of the independent variables, then the function can be written as a first order model (Equation 1.2). In this model the response variables that fit a linear model are generally variables that are significantly affected by a small change in the value of the input factors and that exhibit little or no interaction(s) between the input variable terms. y= ÃŽ ²0+ ÃŽ ²1x1+ ÃŽ ²2x2+†¦..+ ÃŽ µ Second order equations are used to generate linear and quadratic response equations that exhibit interactions between the input factors and can be represented by Equation 1.3. y= ÃŽ ²0+ ÃŽ ²1x1+ ÃŽ ²2x2+ ÃŽ ²12x12+†¦Ã¢â‚¬ ¦+ ÃŽ µ It has been reported that second order models are also applicable to input factors that exhibit extensive variability over an experimental domain and these relationships are best described using Equation 1.4 y= ÃŽ ²0+ ÃŽ ²1x1+ ÃŽ ²2x2+ ÃŽ ²12x12+ ÃŽ ²11x12+ ÃŽ ²22x22+†¦..+ ÃŽ µ Where y= response x1, x2,..xn = input factors ÃŽ ²0= constant that represents the intercept ÃŽ ²i= coefficient of first order term ÃŽ ²ii= coefficient of second order term ÃŽ ²ij= coefficient of second order interaction The values of the coefficients in the model are generated through multiple linear regression analysis of the data that has been collected. A coefficient with a positive value points to an agonistic effect of the input factor on the response, whereas coefficients with negative values indicate an antagonistic effect. 1.3.4 Choice of Response Surface Design Central Composite Design (CCD) A CCD was originally presented by Box and Wilson and is based on a factorial design with additional points to estimate the curvature of that design. CCD encompasses a full factorial or fractional factorial approach which can be represented, as shown in Figure 1.1, as the eight corners of a cube. There are the six points, known as the axial or star points, located in the centre of each face of the cube with a final point located in the middle of the cube that is known as the centre point 37. The axial points are experimental runs where all but one of the factors to be investigated is set at the intermediate level under consideration. The axial points are all equidistant from the centre point and are denoted using the symbol, alpha (ÃŽ ±). The factors under consideration are usually investigated at five different levels and are always represented by coded values viz., -ÃŽ ±, -1, 0, +1 and +ÃŽ ±. Figure 1.1Schematic diagram representing the levels studied in a Central Composite Design The distance of the axial points from the centre point is dependent on the number of factors investigated in the design and is established using Equation 1.5. ÃŽ ± =2k/4 Where, k= the factor number ÃŽ ± = axial point The number of experiments required for a CCD approach is calculated using Equation 1.6 N= k2+ 2k+ C0 Where, N= the experiment number k= the factor number C0= the replicate number of the central point The number of experiments required in an experimental study is important as it determines how much data will be generated, in addition to being an indicator of the amount of time that will be required to conduct the study. Types of central composite design Central composite design can be divided into three types. Table 1.2 Types of central composite design Box-Behnken Design (BBD) The BBD describes a class of second-order designs based on a three-level incomplete factorial approach which are also represented as coded values viz., -1, 0 and +1 42 . In this design approach, the treatment combinations are located at the midpoint(s) of the edge of the process space and at the centre, as represented in Figure 1.2. Figure 1.2 Schematic diagram representing the levels studied in a Box-Behnken Design The number of experiments for Box-Behnken Designs can be calculated using Equation 1.7. N= 2k (k-1) +C0 Where, N= the number of experiments k= the factor number C0= the replicate number of the central point For experiments in which there are three or less input variables the BBD design offers some advantage over the CCD approach, in that a fewer number of experimental runs are required. However this advantage does not exist when four or more parameters are to be investigated. A further advantage of BBD is that it does not include the need to evaluate situations in which all factors are simultaneously held at their highest and lowest levels. The use of a BBD therefore allows a formulation scientist to avoid undertaking experiments that are to performed under extreme conditions and that may produce substandard results due to the inclusion of data generated from these extreme high and low levels 37. Doehlert Design The Doehlert design is an experimental design approach in which different factors can be studied at different levels simultaneously43. This aspect of the Doehlert design is an important characteristic when using some input variables that may be subject to restrictions such as for example cost or experimental constraints (limited amounts of raw material or limited amount of time available) thereby making it a practical and economic alternative to other, second-order experimental design approaches37.This design describes a circular domain of two input variables, a spherical domain for three input variables and a hyper-spherical space for situations in which more than three input variables are to be investigated and which highlights the uniformity of the input variables to be studied in the experimental domain 37. The schematic design space of a Doehlert design for two variables is shown in Figure 1.3, and is represented by a central point and six points of a regular hexagon. An interesting feature of the Doehlert design is that new factors may be introduced during the course of a study without losing relevant and/or valuable information from the data already generated from the experimental runs that have already been completed. Figure 1.3 Schematic diagram representing the levels studied in a Doehlert Design The number of experiments required for a Doehlert design is determined using Equation 1.8 37 N= k2+ k+ C0 Where, N= the number of experiments k= the factor number C0= the replicate number of the central point 1.3.5 Mathematical Optimization Optimization is a mathematical method used to determine an optimum response and is defined as the most advantageous state of existence of the system under investigation44. Multiple linear regression equations generated from statistically designed experiments provide a description of the change of a response with a change in input factors and further, allows for the determination of input variables that will produce an optimized response. A difficulty that occurs in optimization procedures is the need to establish a compromise between the anticipated response variables. This challenge is often encountered in the process of optimization of tablets where the optimum tablet may be one that has superior strength and little or no friability, yet must also have a short disintegration time. Often an increase in tablet hardness results in an increase in the disintegration time of a tablet and therefore a compromise between these contradictory response variables is necessary to achieve an optimized formulation. 1.3.6 Advantages of RSM The primary advantage of RSM in relation to classical experimental methods and approaches of data evaluation in which only one variable is investigated at a time, is that a large amount of information can be generated from a relatively small number of experiments 38. RSM is therefore less time and cost consuming than the classical approach that requires a large number of experiments to be conducted to be able to explain the behavior of a system 38, 39. A further advantage, with the use of RSM is that it is possible to observe interaction effects of the independent input parameters on the response(s) being monitored 38. The model equation that is generated from the data is able to be used to explain the effect of combinations of independent input variables on the outcome of a process or product. 1.3.7 Disadvantages of RSM A primary disadvantage of RSM is that fitting data to a second order polynomial for systems that contain some curvature is often not well accommodated by the second order polynomials that are produced. If the system cannot be explained by a first or second order polynomial, it may be necessary to reduce the range of independent input variables under consideration as this may then increase the accuracy of the model being considered38. Another disadvantage is that although RSM has the potential to evaluate interaction effects of the independent input parameters, it is unable to be used to explain why an interaction(s) has occurred (210). A further disadvantage is that RSM is poor at predicting the potential outcomes for a system operated outside the range of study under consideration45 1.3.8 Software for Design of experiments Many commercial software packages are available which are either dedicated to experimental design alone or are of a more general statistical type. Software’s dedicated to experimental designs DESIGN EXPERT ECHIP MULTI-SIMPLEX NEMRODW Software for general statistical nature SAS MINITAB